Pharmacogenomics (PGx)

Pharmacogenetics is the relationship between a patient’s unique genetic makeup and their response to certain medications. Genetic mutations can cause either higher or lower rates of metabolism for known drugs.

Testing will specify how quickly your body metabolizes, or filters, any given drug. Some patients are rapid metabolizers, flushing medication so quickly from their system that their body does not benefit from the medication. Poor metabolizers, on the other hand, can be harmed because the normal dose of medicine is too much for their body to metabolize. This test provides a physician vital information that is needed when prescribing medication. This means the right drug for the right patient at the right dose, ultimately optimizing the patients drug therapy outcome.

Pharmacogenetic Test Summary

Test Summary
ANKK1/DRD2 DRD2:Taq1A G/G Unaltered DRD2 function
Apolipoprotein
E
ε3/ε3 Normal APOE function
COMT Val158Met G/G High/Normal COMT Activity
CYP1A2 *1A/*1L Normal Metabolizer- Possible
CYP2B6 *1/*6 Intermediate Metabolizer
CYP2C19 *17/*17 Ultra-Rapid Metabolizer
CYP2C9 *1/*1 Normal Metabolizer
CYP2D6 *10/*17 Intermediate Metabolizer
CYP3A4 *1/*1B Normal Metabolizer
CYP3A5 *3/*6 Poor Metabolizer
Factor II rs1799963 GG Normal Thrombosis Risk
Factor V Leiden rs6025 CC Normal Thrombosis Risk
ITGB3 176T>C T/T Normal Platelet Reactivity
LPA rs10455872 A/A Wild-type for rs10455872
LPA rs3798220 T/T Wild-type for rs3798220
MTHFR c.665C>T GG Normal MTHFR Activity
MTHFR c.1286A>C GT Reduced MTHFR Activity
OPRM1 A118G A/A Normal OPRM1 Function
SLCO1B1 521T>C T/T Normal Function
TPMT *1/*1 Normal Metabolizer
VKORC1 -1639G>A G/G Low Warfarin Sensitivity

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